Greig Tonks, Alex Dunbar and Pat McArthur are set for their Scotland Test debut after being named in the starting XV to face Samoa in South Africa.
Edinburgh Tonks start at full-back while Glasgow duo Dunbar and Pat MacArthur are at centre and hooker.
In addition there are another three uncapped players on the bench in Stevie Lawrie, Peter Horne and Duncan Taylor.
Scotland are in South African for the inaugural quadrangular tournament between South Africa, Scotland, Italy and Samoa.
Head coach Scott Johnson said: “We want to broaden the base and it (selection) gives us the perfect opportunity to see how these guys stand up in Test footy.”
“They have all the artillery coming for our game and we’re going out to compete on all fronts.
“We have 25 Test matches available to us prior to the World Cup. I’ve said regularly that we’re not going to give Test jerseys away but we cannot be exposed to injury issues (come RWC) and the best way to prevent that is to give players opportunities.”
Scotland: Greig Tonks (Edinburgh Rugby); Sean Lamont (Glasgow Warriors), Alex Dunbar (Glasgow Warriors), Matt Scott (Edinburgh Rugby), Tim Visser (Edinburgh Rugby); Tom Heathcote (Bath Rugby), Greig Laidlaw (Edinburgh Rugby); Ryan Grant (Glasgow Warriors), Pat MacArthur (Glasgow Warriors), Euan Murray (Worcester Warriors); Grant Gilchrist (Edinburgh Rugby), Alastair Kellock (Glasgow Warriors); Alasdair Strokosch (Perpignan),Kelly Brown (Saracens, Capt.),Johnnie Beattie (Montpellier).
Replacements: Stevie Lawrie (Edinburgh Rugby), Alasdair Dickinson (Sale Sharks), Geoff Cross (Edinburgh Rugby), Jim Hamilton (Gloucester), Ryan Wilson (Glasgow Warriors), Henry Pyrgos (Glasgow Warriors), Peter Horne (Glasgow Warriors), Duncan Taylor (Saracens) uncapped.