Manu Tuilagi has been named in a 33-man England training squad for the Six Nations game with Wales at Twickenham.
The Leicester Tigers centre, who last played for England in 2014, has been out for 15 months with groin and hamstring problems.
Exeter flanker Dave Ewers is also included in the squad, after recovering from a knee injury.
England squad
Forwards: Kieran Brookes (Northampton Saints), Dan Cole (Leicester Tigers), Luke Cowan-Dickie (Exeter Chiefs), Jack Clifford (Harlequins), Dave Ewers (Exeter Chiefs), Jamie George (Saracens), Dylan Hartley (Northampton Saints), James Haskell (Wasps), Paul Hill (Northampton Saints), Maro Itoje (Saracens), George Kruis (Saracens), Matt Kvesic (Gloucester Rugby), Joe Launchbury (Wasps), Courtney Lawes (Northampton Saints), Joe Marler (Harlequins), Matt Mullan (Wasps), Chris Robshaw (Harlequins), Billy Vunipola (Saracens), Mako Vunipola (Saracens).
Backs: Mike Brown (Harlequins), Danny Care (Harlequins), Elliot Daly (Wasps), Owen Farrell (Saracens),George Ford (Bath Rugby), Alex Goode (Saracens), Sam Hill (Exeter Chiefs), Jonathan Joseph (Bath Rugby), Jack Nowell (Exeter Chiefs), Semesa Rokoduguni (Bath Rugby), Manu Tuilagi (Leicester Tigers), Anthony Watson (Bath Rugby), Marland Yarde (Harlequins), Ben Youngs (Leicester Tigers).