Rob Evans, Tom James and Justin Tipuric ahev all been included in Wales’ starting XV for their Six Nations opener against Ireland in Dublin on Sunday.
Ospreys flanker Tipuric will start at openside with captain Sam Warburton at blindside and Taulupe Faletau at No.8.
Evans gets the nod at loosehead to win his fourth cap while former Exeter flyer James is on the wing
He will form a new look back-three alongside Gareth Anscombe and George North. Anscombe, who made his international debut against Ireland last August, will make his first RBS 6 Nations start as he lines up at full-back
Jonathan Davies returns to the side having recovered from the knee injury that saw him miss the World Cup and will be reunited with Jamie Roberts in midfield.
Dan Biggar and Gareth Davies are the half-backs and they line-up together for the fifth consecutive match.
In the pack Evans is joined in the front-row by Ospreys hooker Scott Baldwin and Scarlets prop Samson Lee.
Luke Charteris and Alun Wyn Jones continue their partnership in the second row as Wasps‘ Bradley Davies will have to wait on the bench to win his 50th cap.
“We are excited by the make-up of the squad, it’s very experienced along with one eye looking to the future,” said Wales Head Coach Warren Gatland.
“Rob (Evans) gets a start at loose-head, he’s played well for us before and deserves a chance looking ahead to the next few years.
“We have been impressed with Tom James’ form for Cardiff Blues and we are excited by the mix of the back-row which has played well together before. It’s great to see Jonathan (Davies) back and alongside Jamie, which makes a pretty experienced midfield. Gareth (Anscombe) at full-back also gives us the option of having two first receivers.
“We have a very experienced bench, with a lot of caps there and hopefully they will come on and make an impact.”
“It’s going to be a physical game. Two years ago they strangled us out of the match and played well and we have to rise to that challenge on Sunday.”
Wales: Gareth Anscombe (Cardiff Blues); George North (Northampton), Jonathan Davies (Clermont), Jamie Roberts (Harlequins), Tom James (Cardiff Blues); Dan Biggar (Ospreys), Gareth Davies (Scarlets); Rob Evans (Scarlets), Scott Baldwin (Ospreys), Samson Lee (Scarlets); Luke Charteris (Racing 92), Alun Wyn Jones (Ospreys); Sam Warburton (Cardiff Blues, Capt.), Justin Tipuric (Ospreys), Taulupe Faletau (NG Dragons).
Replacements: Ken Owens (Scarlets), Gethin Jenkins (Cardiff Blues), Tomas Francis (Exeter), Bradley Davies (Wasps), Dan Lydiate (Ospreys), Lloyd Williams (Cardiff Blues), Rhys Priestland (Bath), Alex Cuthbert (Cardiff Blues).