Manu Tuilagi will make his England return on Saturday in Rome after being named in the matchday 23 to face Italy in the last round of the Six Nations.
The Leicester centre spent the last five months on the sidelines with a pectoral muscle injury but made his return against Newcastle two weeks ago in the Premiership playing 70 minutes.
The 22-year-old powerhouse replaces Alex Goode in the squad and is expected to start on the bench with Luther Burrell and Billy Twelvetrees continuing their partnership in the midfield.
“Manu trained well with us last week and today and is up to speed with the way we want to play,” England head coach Stuart Lancaster said.
“Alex Goode has done well for us off the bench and is naturally disappointed but we believe Manu, with the power and physicality he can bring, is the right choice to be included in the 23 for this game.”
England:
Forwards: David Attwood (Bath), Dylan Hartley (Northampton), Tom Johnson (Exeter), Joe Launchbury (London Wasps), Courtney Lawes (Northampton), Joe Marler (Harlequins), Ben Morgan (Gloucester), Chris Robshaw (Harlequins) , Henry Thomas (Sale), Mako Vunipola (Saracens), David Wilson (Bath), Tom Wood (Northampton), Tom Youngs (Leicester)
Backs: Mike Brown (Harlequins), Luther Burrell (Northampton), Danny Care (Harlequins), Lee Dickson (Northampton), Owen Farrell (Saracens), George Ford (Bath), Jonny May (Gloucester), Jack Nowell (Exeter), Manusamoa Tuilagi (Leicester), Billy Twelvetrees (Gloucester).