England will take on Wales in a one-off Sevens international staged immediately after Sunday's RBS 6 Nations contest between the countries at Twickenham.
The match will be broadcast live during the BBC TV Red Button Six Nations Forum after 5pm.
The teams have met twice this season, England winning 33-12 in Dubai in December and 21-7 in Wellington last month.
England Sevens Head Coach Simon Amor said: “The whole squad is looking forward to the chance of being a part of such a massive rugby occasion at Twickenham Stadium.
“We get great support from the senior coaches and players, and our aim is to perform at a level that does them and the shirt proud as our players fight it out for places at the next two World Series tournaments in Tokyo and Hong Kong.”
England Head Coach Stuart Lancaster said: “Sevens is an important part of the England Rugby programme with an exciting future ahead in the build-up to the Commonwealth Games this summer and we'll be wishing them well on Sunday.
“England have a skilful and athletic squad and sevens is a great spectacle so I know our fans will enjoy watching them in what should be a great game against Wales.”
Wales Sevens Head Coach Gareth Williams said, “This is a fantastic opportunity to be part of such a prestigious rugby occasion. It also provides an opportunity for a number of our development players to stake a claim for a place in the squad to travel to Tokyo and Hong Kong later this month.”
RFU Chief Commercial Officer Sophie Goldschmidt said: “We're delighted to be able to showcase international sevens with England playing Wales on such a great stage in front of our fans. Our thanks go to the BBC who are helping us reach a live television audience via the Red Button with this special game.
“Sevens is exciting, dynamic and reaches a growing global following as it heads towards its debut at the Olympic Games in Rio in 2016.
“Both teams on view at Twickenham Stadium take part in a thriving World Series, which concludes with the Marriott London Sevens on May 10-11, and will be heading for the Commonwealth Games in Glasgow later this year with medals in mind.”