Joe Marler and David Wilson called in to face Argentina
The Harlequins loosehead and the Bath tighthead are part of an all new front row with Northampton captain Dylan Hartley is given a chance to impress at hooker.
As a result, Tom Youngs and Dan Cole drop to the bench ahead of the clash against New Zealand next week while Alex Corbisiero has recovered from his knee injury to sit on the bench.
The other change comes on the wing with Ben Foden replacing Marlan Yarde on the left wing. The London Irish winger failed a fitness test on a hip injury so he misses out.
London Wasps flyer Christian Wade, who scored two sensational tries against Gloucester last weekend, was set for his first Test start at HQ but he has a tight hamstring so the out-of-form Chris Ashton has yet another chance to prove his worth on the right wing.
Despite a poor showing last week in the 20-13 win over Australia, Billy Twelvetrees remains at inside centre with Joel Tomkins outside him.
Star man Mike Brown keeps the No.15 shirt while powerhouse Billy Vunipola is at No.8.
On the bench, lock Geoff Parling comes back after his concussion while Saracens full-back Alex Goode has been recalled.
On Friday, Danny Care was also added to the bench after Ben Youngs failed to recover in time from a hip injury.
England Head Coach Stuart Lancaster said: “Joe Marler was excellent off the bench against Australia and merits his opportunity, as does David Wilson, who has been pushing hard for selection.
“Dylan gets a deserved chance at hooker with Tom Youngs on the bench after the safe arrival of his first child this morning. Rob Webber remains on standby.
“Christian Wade was in contention for a start but his hamstring tightened up in training and unfortunately he hasn't recovered sufficiently in time to be considered for Saturday. Maland Yarde failed a fitness test on a hip injury sustained last weekend this morning so Ben Foden gets his chance with Alex Goode on the bench. Ben has had a full week's training on the wing, he is a great finisher and in form so it's a great option for us.
“The Twickenham crowd was superb against Australia and we were pleased to get the victory but we know there's more to come from this team and we are looking forward to building on that momentum for this weekend.”
England: Mike Brown; Chris Ashton, Joel Tomkins, Billy Twelvetrees, Ben Foden; Owen Farrell, Lee Dickson; Joe Marler, Dylan Hartley, David Wilson; Joe Launchbury, Courtney Lawes; Tom Wood, Chris Robshaw (Capt.), Billy Vunipola.
Replacements: Tom Youngs, Alex Corbiero, Dan Cole, Geoff Parling, Ben Morgan, Danny Care, Toby Flood, Alex Goode.
