Frans Malherbe will make his South Africa Test debut against Wales at the Millennium Stadium on Saturday while the experienced JP Pietersen and Jaque Fourie return in the back line.
22-year-old Malherbe comes in for the injured Jannie du Plessis, while the only other change to the pack of forwards is at lock, with Flip van der Merwe starting next to Eben Etzebeth in the middle row.
Promising lock Pieter-Steph du Toit could also make his Test debut for the Springboks if he comes off the bench while Bath’s Francois Louw is name once again at openside.
“Frans has big boots to fill, but he’s been with us for most of 2012 and shown good form since recovering from injury recently and we don’t have any doubts that he has what it takes to make the step up,” said Meyer.
“He’ll have two players with more than 50 Test caps each next to him in the scrum, and his general work-rate across the field and on defence is very good. I’m very happy for Frans.”
“We’re very fortunate to have two world-class players in JP and Jaque available for selection and I wanted to get then into the action as soon as possible,” said Meyer.
“They bring a vast amount of experience to the team and it was clear from our training sessions thus far that they are in great form and ready for Test rugby.”
South Africa: Pat Lambie; JP Pietersen, Jaque Fourie, Jean de Villiers (Capt.), Bryan Habana; Morné Steyn, Fourie du Preez; Tendai Mtawarira, Bismarck du Plessis, Frans Malberhe; Eben Etzebeth, Flip van der Merwe; Francois Louw, Willem Alberts, Duane Vermeulen.
Replacements: Adriaan Strauss, Gurthrö Steenkamp, Coenie Oosthuizen, Pieter-Steph du Toit, Siya Kolisi, Ruan Pienaar, JJ Engelbrecht, Willie le Roux.