Joel Tomkins to earn first England cap against Australia
The Saracens centre will partner Billy Twelvetrees in the midfield while his club teammate Billy Vunipola and London Irish wing Marland Yarde, who both won their first caps in Argentina in June also start at No.8 and wing.
Northampton scrum-half Lee Dickson is rewarded for his superb form of late and partners Owen Farrell at halfback.
Following a stunning display against Gloucester last weekend in the West Country derby, Bath lock Dave Atwood has been named on the bench as Joe Launchbury and Courtney Lawes start in the engine room.
There is an all British & Irish Lions front row with Mako Vunipola, Tom Youngs and Dan Cole, a fourth victorious Lion is on the bench in Ben Youngs.
England Head Coach Stuart Lancaster said: “I’m delighted for Joel. He has had a great week’s training and is ready for his chance. He has played in many high-profile games in his career so far and has a great temperament for the big occasion.
“Billy Vunipola and Marland Yarde made a big impression in Argentina and it’s going to be a special occasion for them to run out at Twickenham in front of 82,000 passionate supporters for the first time.
“We are looking forward to the challenge of playing Australia – they have made great strides under Ewen McKenzie and their new coaching team and they are formidable opponents.
“It’s eight months since we played at our home and we are looking forward to getting back there for the QBE Internationals and what is a very important series for us two years out from the World Cup.”
England: Mike Brown; Chris Ashton, Joel Tomkins, Billy Twelvetrees, Marland Yarde; Owen Farrell, Lee Dickson; Mako Vunipola, Tom Youngs, Dan Cole; Joe Launchbury, Courtney Lawes; Tom Wood, Chris Robshaw (Capt.), Billy Vunipola.
Replacements: Dylan Hartley, Joe Marler, David Wilson, Dave Attwood, Ben Morgan, Ben Youngs, Toby Flood, Ben Foden.
