Henry Slade returns to steer Exeter from fly-half as one of five changes after being rested for their opening Pool 1 defeat by the Sharks in Durban.
The other alterations come in the pack as props Will Goodrick-Clarke and Ehren Painter, lock Rusi Tuima and No.8 Ross Vintcent are all recalled.
Toulouse have made four changes from the side which started the defence of their title with a nine-try thumping of Ulster. Juan Cruz Mallia is named on the wing, with prop Rodrigue Neti, hooker Julien Marchand and flanker Francois Cros all starting.
Exeter, who are bottom of the Premiership table, be...