Lennox Anyanwu starts at inside-centre for Harlequins as they begin life without South African talisman Andre Esterhuizen.
The 23-year-old has filled in when Esterhuizen has been on international duty and now gets the chance to stake his claim for the jersey.
Luke Northmore is alongside him wearing the No.13 jersey, with Oscar Beard selected on the wing.
Nick David is set to earn his 50th Harlequins cap, alongside competitive debuts for new recruits Titi Lamositele at tight-head and Leigh Halfpenny at full-back.

Start: Lennox Anyanwu
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