Worcester Warriors v Northampton Saints (Friday)
Worcester Warriors: 15 Chris Pennell, 14 Bryce Heem, 13 Francois Venter, 12 Ryan Mills, 11 Josh Adams, 10 Duncan Weir, 9 Francois Hougaard; 1 Callum Black, 2 Jack Singleton, 3 Nick Schonert, 4 Anton Bresler, 5 Michael Fatialofa, 6 Marco Mama, 7 Sam Lewis, 8 GJ van Velze (capt).
Replacements: 16 Joe Taufete’e, 17 Ethan Waller, 18 Gareth Milasinovich, 19 Pierce Phillips, 20 Ted Hill, 21 Jonny Arr, 22 Ollie Lawrence, 23 Scott van Breda.
Northampton Saints: 15 Ahsee Tuala, 14 Tom Collins, 13 Luther Burrell, 12 Piers Francis, 11 Taqele Naiyaravoro, 10 Dan Biggar, 9 Cobus Reinach; 1 Alex Waller (co-capt), 2 Dylan Hartley (co-capt), 3 Paul Hill, 4 David Ribbans, 5 Courtney Lawes, 6 Tom Wood, 7 Lewis Ludlam, 8 Teimana Harrison.
Replacements: 16 James Fish, 17 Francois Van Wyk, 18 Ben Franks, 19 Api Ratuniyarawa, 20 Jamie Gibson, 21 Heinrich Brüssow, 22 Alex Mitchell, 23 Fraser Dingwall.
Exeter Chiefs v Saracens (Saturday)
Exeter Chiefs: 15 Joe Simmonds, 14 Santiago Cordero, 13 Ian Whitten, 12 Sam Hill, 11 Tom O’Flaherty, 10 Gareth Steenson, 9 Jack Maunder; 1 Alec Hepburn, 2 Jack Yeandle (capt), 3 Tomas Francis, 4 Dave Dennis, 5 Sam Skinner, 6 Sean Lonsdale, 7 Don Armand, 8 Matt Kvesic.
Replacements: 16 Luke Cowan-Dickie, 17 Ben Moon, 18 Harry Williams, 19 Mitch Lees, 20 Tom Lawday, 21 Nic White, 22 Ollie Devoto, 23 Phil Dollman.
Saracens: 15 Alex Goode, 14 Alex Lozowski, 13 Nick Tompkins, 12 Brad Barritt, 11 Alex Lewington, 10 Owen Farrell, 9 Ben Spencer; 1 Mako Vunipola, 2 Jamie George, 3 Vincent Koch, 4 Nick Isiekwe, 5 George Kruis, 6 Mike Rhodes, 7 Calum Clark, 8 Ben Earl.
Replacements: 16 Tom Woolstencroft, 17 Richard Barrington, 18 Christian Judge, 19 Dom Day, 20 Will Skelton, 21 Schalk Burger, 22 Tom Whiteley, 23 Matt Gallagher.
Leicester Tigers v Harlequins (Saturday)
Leicester Tigers: 15 George Worth, 14 Jonah Holmes, 13 Manu Tuilagi, 12 Matt Toomua, 11 Jonny May, 10 George Ford (capt), 9 Ben Youngs; 1 Ellis Genge, 2 Tatafu Polota-Nau, 3 Dan Cole, 4 Harry Wells, 5 Will Spencer, 6 Mike Fitzgerald, 7 Guy Thompson, 8 Sione Kalamafoni.
Replacements:16 Jake Kerr, 17 Campese Ma’afu, 18 Joe Heyes, 19 Mike Williams, 20 Brendon O’Connor, 21 Ben White, 22 Gareth Owen, 23 Jordan Olowofela.
Harlequins: 15 Mike Brown, 14 Nathan Earle, 13 Joe Marchant, 12 Paul Lasike, 11 Cadan Murley, 10 James Lang, 9 Charlie Mulchrone; 1 Joe Marler, 2 Dave Ward, 3 Kyle Sinckler, 4 Matt Symons, 5 George Merrick, 6 Alex Dombrandt, 7 Jack Clifford, 8 James Chisholm (capt).
Replacements:16 Max Crumpton, 17 Lewis Boyce, 18 Will Collier, 19 Ben Glynn, 20 Renaldo Bothma, 21 Dave Lewis, 22 Marcus Smith, 23 Alofa Alofa.
Sale Sharks v Bristol Bears (Saturday)
Sale Sharks: 15 Chris Ashton, 14 Denny Solomona, 13 Sam James, 12 James O’Connor, 11 Byron McGuigan, 10 Rob du Preez, 9 Faf de Klerk; 1 Ross Harrison, 2 Rob Webber, 3 WillGriff John, 4 Josh Beaumont, 5 James Phillips, 6 Jono Ross (capt), 7 Tom Curry, 8 Jean-Luc du Preez.
Replacements: 16 Curtis Langdon, 17 Tom Bristow, 18 Joe Jones, 19 Bryn Evans, 20 Josh Strauss, 21 Will Cliff, 22 Luke James, 23 Ben Curry.
Bristol Bears: 15 Charles Piutau, 14 Luke Morahan, 13 Will Hurrell, 12 Siale Piutau (co-capt), 11 Alapati Leiua, 10 Ian Madigan 9 Harry Randall; 1 Yann Thomas, 2 Harry Thacker, 3 John Afoa, 4 Chris Vui, 5 Aly Muldowney, 6 Steve Luatua (co-capt), 7 George Smith, 8 Jack Lam.
Replacements: 16 Tom Lindsay, 17 Jake Woolmore, 18 Lewis Thiede, 19 Joe Joyce, 20 Dan Thomas, 21 Andy Uren, 22 Callum Sheedy, 23 Piers O’Conor.
Newcastle Falcons v Gloucester (Sunday)
Newcastle Falcons: 15 Simon Hammersley, 14 Vereniki Goneva, 13 Chris Harris, 12 Josh Matavesi, 11 Alex Tait, 10 Toby Flood (capt), 9 Sonatane Takulua; 1 Sam Lockwood, 2 Kyle Cooper, 3 Logovi’i Mulipola, 4 Calum Green, 5 Tevita Cavubati, 6 Gary Graham, 7 John Hardie, 8 Mark Wilson.
Replacements: 16 George McGuigan, 17 Trevor Davison, 18 David Wilson, 19 Andrew Davidson, 20 Ryan Burrows, 21 Michael Young, 22 Brett Connon, 23 Tom Arscott.
Gloucester: 15 Jason Woodward, 14 Charlie Sharples, 13 Billy Twelvetrees, 12 Tom Hudson, 11 Ollie Thorley, 10 Owen Williams, 9 Callum Braley; 1 Josh Hohneck, 2 Jaco Visagie, 3 Ciaran Knight, 4 Ed Slater (capt), 5 Franco Mostert, 6 Freddie Clarke, 7 Lewis Ludlow, 8 Ben Morgan.
Replacements: 16 Henry Walker, 17 Paddy McAllister, 18 Fraser Balmain, 19 Tom Savage, 20 Gareth Evans, 21 Willi Heinz, 22 Henry Trinder, 23 Jaco Kriel.
Wasps v Bath (Sunday)
Wasps: 15 Willie Le Roux, 14 Ross Neal, 13 Elliot Daly, 12 Michael Le Bourgeois, 11 Josh Bassett, 10 Billy Searle, 9 Craig Hampson; 1 Ben Harris, 2 Ashley Johnson (capt), 3 Jake Cooper-Woolley, 4 Will Rowlands, 5 Kearnan Myall, 6 Brad Shields, 7 Thomas Young, 8 Nizaam Carr.
Replacements: 16 Tom Cruse, 17 Zurabi Zhvania, 18 Kieran Brookes, 19 Charlie Matthews, 20 Nathan Hughes, 21 Dan Robson, 22 Lima Sopoaga, 23 Michele Campagnaro.
Bath: 15 James Wilson, 14 Semesa Rokoduguni, 13 Max Wright, 12 Jamie Roberts, 11 Ruaridh McConnochie, 10 Freddie Burns, 9 Will Chudley (capt); 1 Nathan Catt, 2 Tom Dunn, 3 Henry Thomas, 4 Dave Attwood, 5 Elliott Stooke, 6 Tom Ellis, 7 Sam Underhill, 8 Francois Louw.
Replacements: 16 Ross Batty, 17 Jacques van Rooyen, 18 Max Lahiff, 19 Matt Garvey, 20 Zach Mercer, 21 Max Green, 22 Max Clark, 23 Cooper Vuna.